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DTSTART;TZID=America/Los_Angeles:20260129T114000
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DTSTAMP:20260421T163746
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SUMMARY:BME 280B Seminar: Satellite repeats encode megabase-scale transcription factor hubs
DESCRIPTION:Presenter: Matt Franklin\, Postdoctoral Researcher\, Stanford University \nDescription: Eukaryotic genomes contain large stretches of repetitive DNA called satellite DNA\, often found near centromeres and ribosomal DNA regions. In humans\, alpha satellite has well-established roles in centromere biology\, however the functions of other human satellite DNAs remain largely unexplored. \nWe recently identified the Hippo pathway effector TEAD as a novel Human Satellite 3 (HSat3) binding TF. Because HSat3 is highly enriched near ribosomal DNA (rDNA) genes\, we examined whether the Hippo pathway regulates rDNA via HSat3. Our work demonstrates that HSat3 localizes the Hippo factors YAP and TEAD inside the nucleolus\, where YAP directly activates ribosomal RNA (rRNA) transcription. These findings present the first evidence that the Hippo pathway factor YAP directly regulates RNA Polymerase I activity. \nDisparate studies have identified examples of transcription factors that bind repetitive DNA elements through motif recognition. However\, a systematic search for such factors has not been conducted. Using Telomere-to-telomere genome assemblies\, we predicted and validated dozens of new satellite-binding TFs\, many of which are part of highly conserved signaling pathways. Beyond revealing a direct relationship between the Hippo pathway and ribosomal DNA regulation\, this work demonstrates that satellite DNA can encode a broad range of functional motifs\, hinting at new roles for these enormous genomic elements. \nBio: Following his undergraduate studies\, Matt conducted a 1-year research fellowship at EMBL Hamburg\, where he worked on X-ray scattering methods for structural biology. He then earned his PhD in chemical engineering at Stanford University\, where he investigated mechanotransduction and Hippo pathway signaling. Matt continued this research as a postdoc under Kun-Liang Guan at UC San Diego\, where he discovered that Hippo pathway effectors bind repetitive DNA elements. To expand on his newfound interest in repetitive DNA\, Matt returned to Stanford as a postdoctoral researcher under Nicolas Altemose\, where he is studying the functions of satellite repeats as hubs for transcription factor binding. \nHosted by: Professor Karen Miga\, BME Department
URL:https://events.ucsc.edu/event/bme-280b-seminar-satellite-repeats-encode-megabase-scale-transcription-factor-hubs/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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DTSTART;TZID=America/Los_Angeles:20260129T130000
DTEND;TZID=America/Los_Angeles:20260129T163000
DTSTAMP:20260421T163746
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SUMMARY:Allen van Gelder Memorial
DESCRIPTION:You are cordially invited to an event celebrating the life and research legacy of Allen van Gelder\, who passed away in April 2025 after 37 years of dedicated service to the Computer Science and Engineering Department at UC Santa Cruz. \nThursday\, January 29\, 2025\nReception begins 1pm\, Program begins 1:30pm\nAlumni Room\, University Center\, UC Santa Cruz \nPlease RSVP via the following link:\nhttps://forms.gle/iyFTL2aAxLMWdRMU9 \nThe gathering will include three presentations reflecting on Allen’s contributions to computer science\, followed by an opportunity for attendees to share remembrances and stories \nOn Allen’s contributions to databases and logic programming\nJeff Ullman\, Stanford W. Ascherman Professor of Computer Science (Emeritus)\, Computer Science Department\, Stanford University \nOn Allen’s contributions to computer graphics and visualization\nClaudio Silva\, Institute Professor of Computer Science and Engineering\, NYU Tandon School of Engineering\, New York University \nOn Allen’s contributions to satisfiability\nOlaf Beyersdorff\, Professor of Theoretical Computer Science\, Institute of Computer Science\, Friedrich Schiller University Jena \nWhether you were a colleague\, student\, or friend\, we hope you’ll join us in celebrating Allen’s career and its impact.
URL:https://events.ucsc.edu/event/allen-van-gelder-memorial/
LOCATION:University Center\, University Center\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars,Social Gathering
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DTSTART;TZID=America/Los_Angeles:20260129T173000
DTEND;TZID=America/Los_Angeles:20260129T183000
DTSTAMP:20260421T163746
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SUMMARY:Unlock Your Career: 10 Essential Strategies for Success in an AI-Driven World
DESCRIPTION:Are you ready to thrive in today’s fast-moving professional world — especially in one shaped by innovation\, technology\, and AI?  Success in today’s AI-driven economy requires more than technical skills—it demands the right mindset\, habits\, and career strategy. Whether you’re early in your career\, navigating a transition\, or pushing for your next breakthrough\, this workshop will help you accelerate your professional impact with confidence and clarity. \nIn this Dean Series workshop\, Dean PK Agarwal shares practical\, real-world insights drawn from leadership roles across industry\, academia\, and government. Participants will learn how to create value in any role\, stay relevant as careers evolve\, and build professional resilience in times of change. \n\nIdentify the traits and mindsets that separate high performers from the rest\nLearn how to add value and stand out in any organization\nExplore strategies for continuous learning in an AI-enabled workplace\nPick up tips to build and leverage professional networks effectively\nGain insight into managing up and taking ownership of your career trajectory\nExamine your brand\, both in person and online\n\nThis event is part of the Dean Conversations: Pathways to professional success series.  \nClaim your seat!
URL:https://events.ucsc.edu/event/10-tips-for-career-success/
LOCATION:Silicon Valley Campus\, 3175 Bowers Avenue\, Santa Clara\, CA\, 95054\, United States
CATEGORIES:Lectures & Presentations,Meetings & Conferences,Training
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DTSTART;TZID=America/Los_Angeles:20260129T180000
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SUMMARY:Pesticide Impacts in and around Monterey Bay lecture
DESCRIPTION:The short- and long-term health impacts of pesticide use for local communities on land as well as in the ocean are addressed in a conversation with Yanely Martinez\, Katherine Gabriel-Cox\, Adam Scow and Logan Pallin. \nThis event is presented as part of as part of the Intersections of Climate Change series\, and is organized with the Friedlaender Lab\, in conjunction with the Weather and the Whale exhibition\, at the Institute of the Arts and Sciences.\n—\nFULL SCHEDULE OF EVENTS\n– Thu.\, Jan. 29\, 6:00 p.m.: Pesticide Impacts in and around Monterey Bay\n– Thu.\, Feb. 5\, 6:00 p.m.: Climate Justice and the Moss Landing Battery Fire\n– Wed.\, Feb. 11\, 6:00 p.m.: The California Firefighter Cancer Research Study with Shehnaz Hussain and Fire Captain Jamie Gabriel\n– Thu.\, Feb. 26\, 6:00 p.m.: The Whale Liberation Front—An electroacoustic performance and artist talk\n– Wed.\, March 4\, 6:00 p.m.: Unexpected Returns: The Historic Entanglements of Fire\, Settlement\, and Stewardship in the Santa Cruz Mountains\n—\nADMISSION\n– FREE and open to the public\n– Attend in person at the UC Santa Cruz Institute of the Arts and Sciences on the Westside in Santa Cruz\, Calif.\n—\nPARKING\n– The entrance to the Institute of the Arts and Sciences is on Delaware St. and has an accessibility ramp.\n– Free self-parking is available on Panetta Ave. and High Rd.\, immediately adjacent to the building.\n– Accessible parking is on High Rd.\n—\nThis program is open to all members of the public consistent with state and federal law.
URL:https://events.ucsc.edu/event/pesticides-impacts-in-and-around-monterey-bay-lecture/
LOCATION:Institute of the Arts and Sciences\, 100 Panetta Ave\, Santa Cruz\, United States
CATEGORIES:Lectures & Presentations
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