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DTSTART;TZID=America/Los_Angeles:20251204T114000
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SUMMARY:BME 280B Seminar: Gali Bai & David Haussler
DESCRIPTION:Presenter 1: Gali Bai\, BME/PBSE Doctoral Candidate\, Brooks Lab\, UC Santa Cruz \nTitle 1: Dissecting the contribution of chromatin accessibility to RNA transcription and processing with long-read sequencing \nDescription: Although all cells in an organism share the same genomic sequence\, transcriptional programs vary dramatically across cell types. This diversity is governed by epigenetic regulation involving the coordinated activities of chromatin remodelers\, histone modifiers\, and histone chaperones that precisely modulate chromatin accessibility. While previous studies have shown that chromatin accessibility at DNase I–hypersensitive sites such as promoters and enhancers is closely associated with gene expression\, much less is known about how chromatin influences transcription and RNA processing. To study how chromatin regulates RNA processing\, we perturbed yeast chromatin accessibility by deleting two highly conserved chromatin remodelers ISW1 and CHD1. With Oxford Nanopore long-read sequencing\, we profiled nascent RNA\, full-length mRNA\, and chromatin fibers in wild-type and chd1 isw1 double-mutant yeast cells. Loss of ISW1 and CHD1 led to increased chromatin accessibility within intragenic regions\, accompanied by aberrant transcription initiation. Leveraging long-read data\, we associated distinct chromatin states with specific RNA processing events and isoform expression outcomes. Despite a similar level of chromatin perturbations across the genome\, genes with low baseline expression showed extensive transcriptional reprogramming\, whereas highly expressed genes remained largely unaffected. These discrepancies can be partially explained by differences in the enrichment of transcription initiation motifs. In intron-containing genes\, loss of ISW1 and CHD1 reduced splicing efficiency and increased intron retention\, likely due to disrupted RNAPII elongation in the double mutant. Together\, our findings highlight the crucial role of ATP-dependent chromatin remodelers in maintaining nucleosome organization and coordinating co-transcriptional RNA processing. \nPresenter 2: David Haussler\, Distinguished Professor\, UC Santa Cruz \nTitle 2: Brain Organoids \nBio: Haussler received his PhD in computer science from the University of Colorado at Boulder. He is a member of the National Academy of Sciences\, the National Academy of Engineering\, the American Academy of Arts and Sciences and a fellow of AAAS and AAAI. He has won a number of awards\, including the 2015 Dan David Prize\, the 2011 Weldon Memorial Prize from University of Oxford\, the 2009 ASHG Curt Stern Award in Human Genetics\, the 2008 Senior Scientist Accomplishment Award from the International Society for Computational Biology\, the 2005 Dickson Prize for Science from Carnegie Mellon University\, and the 2003 ACM/AAAI Allen Newell Award in Artificial Intelligence. \nHosted by: Professor Josh Stuart\, BME Department
URL:https://events.ucsc.edu/event/bme-280b-seminar-gali-bai-david-haussler/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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DTSTART;TZID=America/Los_Angeles:20251204T134000
DTEND;TZID=America/Los_Angeles:20251204T150000
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SUMMARY:Behavioral\, Econometrics and Theory Seminar Series Presents: Jacopo Magnani
DESCRIPTION:Economics Behavioral\, Econometrics\, & Theory Seminar\nDate: Thursday\, December 4\, 2025\nTime: 1:40-3:00 p.m.\nLocation: E2-499\n\n \n\nSpeaker: Jacopo Magnani \nTitle:  Associate Professor of Economics \nAffiliation: Norwegian University of Science and Technology\, visiting Caltech\nHost: Kristian Lopez Vargas\n \nSeminar title: Behavioral Limits to Complete Markets\n \nABSTRACT:  Standard economic theory predicts that individuals should prefer complete markets to incomplete markets\, as the former allow state-contingent claims for every possible outcome. Yet real-world markets remain incomplete\, and the demand-side origins of the phenomenon are poorly understood. We develop an experimental framework to examine whether investors may themselves prefer incomplete markets\, and highlight two potential mechanisms: preference instability\, which exposes agents to greater regret or temptation in complete markets\, and complexity costs\, which arise because higher dimensionality increases cognitive effort and errors. In our experiment\, participants consistently reveal a preference for in complete markets\, contradicting the rational benchmark. Comparing homegrown and induced-preference treatments\, we find no evidence that this behavior is driven by preference instability. Instead\, utility losses\, response times\, and subjective ratings indicate that complexity costs drive the preference for incompleteness. Structural estimation confirms that complete markets are several times more complex than incomplete ones\, providing a behavioral foundation for market incompleteness. 
URL:https://events.ucsc.edu/event/behavioral-econometrics-and-theory-seminar-series-presents-jacopo-magnani/
LOCATION:Engineering 2\, Engineering 2 1156 High Street\, Santa Cruz\, CA\, 95064
CATEGORIES:Seminars
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