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DTSTART;TZID=America/Los_Angeles:20260129T114000
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SUMMARY:BME 280B Seminar: Satellite repeats encode megabase-scale transcription factor hubs
DESCRIPTION:Presenter: Matt Franklin\, Postdoctoral Researcher\, Stanford University \nDescription: Eukaryotic genomes contain large stretches of repetitive DNA called satellite DNA\, often found near centromeres and ribosomal DNA regions. In humans\, alpha satellite has well-established roles in centromere biology\, however the functions of other human satellite DNAs remain largely unexplored. \nWe recently identified the Hippo pathway effector TEAD as a novel Human Satellite 3 (HSat3) binding TF. Because HSat3 is highly enriched near ribosomal DNA (rDNA) genes\, we examined whether the Hippo pathway regulates rDNA via HSat3. Our work demonstrates that HSat3 localizes the Hippo factors YAP and TEAD inside the nucleolus\, where YAP directly activates ribosomal RNA (rRNA) transcription. These findings present the first evidence that the Hippo pathway factor YAP directly regulates RNA Polymerase I activity. \nDisparate studies have identified examples of transcription factors that bind repetitive DNA elements through motif recognition. However\, a systematic search for such factors has not been conducted. Using Telomere-to-telomere genome assemblies\, we predicted and validated dozens of new satellite-binding TFs\, many of which are part of highly conserved signaling pathways. Beyond revealing a direct relationship between the Hippo pathway and ribosomal DNA regulation\, this work demonstrates that satellite DNA can encode a broad range of functional motifs\, hinting at new roles for these enormous genomic elements. \nBio: Following his undergraduate studies\, Matt conducted a 1-year research fellowship at EMBL Hamburg\, where he worked on X-ray scattering methods for structural biology. He then earned his PhD in chemical engineering at Stanford University\, where he investigated mechanotransduction and Hippo pathway signaling. Matt continued this research as a postdoc under Kun-Liang Guan at UC San Diego\, where he discovered that Hippo pathway effectors bind repetitive DNA elements. To expand on his newfound interest in repetitive DNA\, Matt returned to Stanford as a postdoctoral researcher under Nicolas Altemose\, where he is studying the functions of satellite repeats as hubs for transcription factor binding. \nHosted by: Professor Karen Miga\, BME Department
URL:https://events.ucsc.edu/event/bme-280b-seminar-satellite-repeats-encode-megabase-scale-transcription-factor-hubs/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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DTSTART;TZID=America/Los_Angeles:20260129T130000
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SUMMARY:Allen van Gelder Memorial
DESCRIPTION:You are cordially invited to an event celebrating the life and research legacy of Allen van Gelder\, who passed away in April 2025 after 37 years of dedicated service to the Computer Science and Engineering Department at UC Santa Cruz. \nThursday\, January 29\, 2025\nReception begins 1pm\, Program begins 1:30pm\nAlumni Room\, University Center\, UC Santa Cruz \nPlease RSVP via the following link:\nhttps://forms.gle/iyFTL2aAxLMWdRMU9 \nThe gathering will include three presentations reflecting on Allen’s contributions to computer science\, followed by an opportunity for attendees to share remembrances and stories \nOn Allen’s contributions to databases and logic programming\nJeff Ullman\, Stanford W. Ascherman Professor of Computer Science (Emeritus)\, Computer Science Department\, Stanford University \nOn Allen’s contributions to computer graphics and visualization\nClaudio Silva\, Institute Professor of Computer Science and Engineering\, NYU Tandon School of Engineering\, New York University \nOn Allen’s contributions to satisfiability\nOlaf Beyersdorff\, Professor of Theoretical Computer Science\, Institute of Computer Science\, Friedrich Schiller University Jena \nWhether you were a colleague\, student\, or friend\, we hope you’ll join us in celebrating Allen’s career and its impact.
URL:https://events.ucsc.edu/event/allen-van-gelder-memorial/
LOCATION:University Center\, University Center\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars,Social Gathering
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