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SUMMARY:Seminar Series | What you may not know about groundwater management in California with Ruth Langridge
DESCRIPTION:Host: ENVS Personnel Committee \nGroundwater is a critical source of California’s water supply. Many basins in critical overdraft are now being managed under the 2015 Sustainable Groundwater Management Act (SGMA) to support state goals of sustainable and equitable management. However\, court adjudicated basins that encompass over 8\,000 square miles and are home to nearly 11 million people\, over 4 million of whom live in disadvantaged and economically vulnerable communities\, are not managed under SGMA but under court judgments. The groundwater basins in the entire San Gabriel River Watershed and large areas of the Santa Ana Watershed in Southern California are adjudicated. Our research evaluated how management of these important groundwater basins under a court appointed Watermaster is aligned with state sustainability and equity goals as expressed in SGMA. \nIn person and on Zoom \nMeeting ID:  949 5253 7079 \nPasscode: 552886
URL:https://events.ucsc.edu/event/groundwater-management-in-california/
LOCATION:Interdisciplinary Sciences Building\, 7487 Red Hill Road\, Santa Cruz\, CA\, 95064
CATEGORIES:Seminars
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DTSTART;TZID=America/Los_Angeles:20260601T160000
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SUMMARY:AM Seminar: Using Math and Experiments to Study the Control of Cell Metabolism
DESCRIPTION:Presenter: Denis Titov\, Assistant Professor\, University of California\, Berkeley \nDescription: Cells run thousands of chemical reactions simultaneously\, and these reactions must be precisely controlled—like a thermostat that prevents overheating. When this control fails\, diseases including diabetes\, cardiovascular disease\, and fatty liver disease result. One key control mechanism is allosteric regulation\, where a small molecule binds to an enzyme and changes its activity. Allosteric regulation is among the most conserved features of cellular life\, yet the functions it serves remain one of the oldest unsolved problems in biology. Several roles have been proposed\, but since the discovery of allostery in the 1950s\, no one has systematically disabled it in metabolic enzymes and measured the consequences. Four technological advances now converge to make this possible. CRISPR enables precise genome editing of allosteric sites. Structural biology has mapped which residues to target. LC-MS metabolomics makes metabolic phenotyping routine. The speed of modern computers enables detailed modeling of allosteric regulator function. In this talk\, I will describe our work developing and testing the first-in-class biophysical model of a metabolic pathway that accurately predicts responses to the addition or removal of allosteric regulators. Our work provides a framework for developing predictive models of cell metabolism that can be used for drug development or for engineering cells for energy production and chemical synthesis. Within a decade\, we plan to develop a model that accurately predicts metabolic activity in any human cell type under any condition. \nAbout the speaker: Denis Titov is an Assistant Professor at the University of California Berkeley with joint appointments in the Department of Metabolic Biology and Nutrition\, Department of Molecular and Cell Biology\, and Center for Computational Biology. Dr. Titov’s long-term research dream is to improve the understanding of human metabolic pathway regulation to a point where we can accurately predict metabolic pathway activity in any cell type\, under any condition\, and in response to any perturbation. Dr. Titov is interested in the following broad questions: How does metabolic homeostasis emerge from the activities of individual enzymes? What trade-offs drove the evolution of specific metabolic pathways and their control mechanisms? How to effectively combine data and biophysical models to simulate metabolic pathways? To tackle these questions\, Titov lab is using a combination of biochemistry\, mathematical modeling\, physiology\, custom instrumentation\, and genetically encoded tool development to study metabolism in mammalian cells and reconstituted biochemical systems. \nThis seminar is hosted by Professor Nilah Ioannidis.
URL:https://events.ucsc.edu/event/am-seminar-using-math-and-experiments-to-study-the-control-of-cell-metabolism/
LOCATION:Jack Baskin Engineering\, Baskin Engineering 1156 High Street\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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