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SUMMARY:AM Seminar: Using Math and Experiments to Study the Control of Cell Metabolism
DESCRIPTION:Presenter: Denis Titov\, Assistant Professor\, University of California\, Berkeley \nDescription: Cells run thousands of chemical reactions simultaneously\, and these reactions must be precisely controlled—like a thermostat that prevents overheating. When this control fails\, diseases including diabetes\, cardiovascular disease\, and fatty liver disease result. One key control mechanism is allosteric regulation\, where a small molecule binds to an enzyme and changes its activity. Allosteric regulation is among the most conserved features of cellular life\, yet the functions it serves remain one of the oldest unsolved problems in biology. Several roles have been proposed\, but since the discovery of allostery in the 1950s\, no one has systematically disabled it in metabolic enzymes and measured the consequences. Four technological advances now converge to make this possible. CRISPR enables precise genome editing of allosteric sites. Structural biology has mapped which residues to target. LC-MS metabolomics makes metabolic phenotyping routine. The speed of modern computers enables detailed modeling of allosteric regulator function. In this talk\, I will describe our work developing and testing the first-in-class biophysical model of a metabolic pathway that accurately predicts responses to the addition or removal of allosteric regulators. Our work provides a framework for developing predictive models of cell metabolism that can be used for drug development or for engineering cells for energy production and chemical synthesis. Within a decade\, we plan to develop a model that accurately predicts metabolic activity in any human cell type under any condition. \nAbout the speaker: Denis Titov is an Assistant Professor at the University of California Berkeley with joint appointments in the Department of Metabolic Biology and Nutrition\, Department of Molecular and Cell Biology\, and Center for Computational Biology. Dr. Titov’s long-term research dream is to improve the understanding of human metabolic pathway regulation to a point where we can accurately predict metabolic pathway activity in any cell type\, under any condition\, and in response to any perturbation. Dr. Titov is interested in the following broad questions: How does metabolic homeostasis emerge from the activities of individual enzymes? What trade-offs drove the evolution of specific metabolic pathways and their control mechanisms? How to effectively combine data and biophysical models to simulate metabolic pathways? To tackle these questions\, Titov lab is using a combination of biochemistry\, mathematical modeling\, physiology\, custom instrumentation\, and genetically encoded tool development to study metabolism in mammalian cells and reconstituted biochemical systems. \nThis seminar is hosted by Professor Nilah Ioannidis.
URL:https://events.ucsc.edu/event/am-seminar-using-math-and-experiments-to-study-the-control-of-cell-metabolism/
LOCATION:Jack Baskin Engineering\, Baskin Engineering 1156 High Street\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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DTSTART;TZID=America/Los_Angeles:20260605T180000
DTEND;TZID=America/Los_Angeles:20260605T193000
DTSTAMP:20260501T033954
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SUMMARY:Science in the Neighborhood: The earthquake problem
DESCRIPTION:Science In the Neighborhood\nA public lecture series hosted quarterly by the UC Santa Cruz Science Division \nThe earthquake problem\nPresentation by Emily Brodsky\, Professor\, UC Santa Cruz\nQ&A with Stefano Profumo\, Associate Dean of Science\, UC Santa Cruz \nRegister here. \nEarthquake prediction has simultaneously remained both the central\, unsolved problem in seismology and the issue that communities care about most—especially here in Northern California. Earth & Planetary Sciences Professor Emily Brodsky will discuss what we do and do not know about when earthquakes will happen. She will explain what we understand about the basic mechanics of faults and how drilling into faults has transformed our understanding of how earthquakes happen. Her talk will also explore how the machine learning revolution is powering a transformation in forecasting aftershocks\, as well as look ahead toward the kind of instrumentation and approaches that offer the most promise for the next big advances. \nThe event is in-person only. Register here. \nFriday\, June 5\, 2026 | 6:00–7:30 p.m.\nCoastal Biology Building. Rm. 110\nUC Santa Cruz Coastal Campus\n130 McAllister Way\nSanta Cruz\, CA 95060 \nThe screenshot below shows where to find the entrance of the Coastal Biology Building.
URL:https://events.ucsc.edu/event/science-in-the-neighborhood-the-earthquake-problem/
LOCATION:Coastal Biology Building\, 130 McAllister Way\, Santa Cruz\, CA\, 95060
CATEGORIES:Lectures & Presentations
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DTSTART;TZID=America/Los_Angeles:20260606T110000
DTEND;TZID=America/Los_Angeles:20260606T120000
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SUMMARY:First Saturday Tour at the Arboretum
DESCRIPTION:First Saturday Tours are a wonderful way to introduce yourself to the Arboretum or to deepen your knowledge of the Arboretum’s plant collections. Each tour is a little different depending on the time of year\, the interests of the tour guide\, and the people who join in. For example\, you might learn about the birds and mammals that make this land their home or about the amazing physical adaptations that plants have evolved to better deal with our extreme weather and climate conditions. Tours are free with paid admission.
URL:https://events.ucsc.edu/event/first-saturday-tour-at-the-arboretum/2026-06-06/
LOCATION:Arboretum\, 122 Arboretum Road\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations
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