T cell receptors (TCRs) mediate antigen-specific immune responses through recognition of peptides presented by major histocompatibility complex (pMHC) molecules. Accurately predicting TCR–pMHC interactions remains a major barrier to TCR-based immunotherapy, due to limitations in current models that fail to generalize beyond common viral epitopes and well-characterized HLA alleles. In this PhD proposal, I outline a […]

The explosive growth of genomic data, driven by advances in sequencing and inference technologies, presents both an opportunity and a challenge for evolutionary biology and public health. Existing visualization and analysis tools often fall short in handling the scale, complexity, and uncertainty of modern genomic datasets—especially in the areas of pathogen surveillance and ancestral recombination […]

Neurodevelopmental and neuropsychiatric disorders (NPDs), such as autism spectrum disorder and schizophrenia, are among the most heritable yet mechanistically complex conditions. While large-scale genomic studies have identified hundreds of high-confidence risk genes, the lack of scalable and integrative platforms has limited our ability to functionally characterize these genes. To address this, I am developing a […]

Machine learning endows autonomous systems to uncover underlying structures and physical laws from measured data and to leverage these models for prediction and decision-making. As the costs of data acquisition, processing, and storage decline—and sensors become increasingly widespread alongside ever-improving algorithms—artificial intelligence has attracted significant attention in research and industry. Machine-learning methods are particularly attractive […]

Collaborative virtual reality environments have the potential to greatly impact scientific progress, especially those relating to existential human problems. Within these virtual environments, scientists could view and interact with spatial data in applications as part of their sensemaking process, however, there are design challenges and barriers to development. This advancement document presents research questions related […]

Program verification has been applied in many contexts (including videogames), but the scale and complexity of the examples that have been analyzed fall short of the ability to analyze many existing games without massive computational costs. My research focuses on automatic analysis and design of one particular game: Super Metroid, with the goal of creating […]

Reconstructing ocean dynamics from observational data is fundamentally limited by the sparse, irregular, and Lagrangian nature of spatial sampling, particularly in subsurface and remote regions. This sparsity poses significant challenges for forecasting key phenomena such as eddy shedding and rogue waves. Traditional data assimilation methods and deep learning models often struggle to recover mesoscale turbulence […]

Modern machine perception is powerful yet brittle: failing in response to subtle data adversaries and lacking mechanisms to learn from their errors. We address this challenge by progressing from diagnosing such failures to developing a framework for persistent learning. We first investigate the sources of this fragility, demonstrating how both naturally occurring adversarial artifacts, like […]