Decompositions of large-scale networks are central to many applications in graph mining, network science, and algorithm design. Over several decades, a rich body of work has developed techniques to partition […]

Narrative sandbox games rely heavily on simulation to produce emergent narrative experiences. Instead of featuring pre-authored central narratives, these games provide a play space, a sandbox, of various systems and […]

Online communities tell stories with the games they play. As continual updates, recurring monetization, and platforms for community discussions have flourished, we have seen a rise in video games using […]

T cell receptors (TCRs) mediate antigen-specific immune responses through recognition of peptides presented by major histocompatibility complex (pMHC) molecules. Accurately predicting TCR–pMHC interactions remains a major barrier to TCR-based immunotherapy, […]

The explosive growth of genomic data, driven by advances in sequencing and inference technologies, presents both an opportunity and a challenge for evolutionary biology and public health. Existing visualization and […]

Neurodevelopmental and neuropsychiatric disorders (NPDs), such as autism spectrum disorder and schizophrenia, are among the most heritable yet mechanistically complex conditions. While large-scale genomic studies have identified hundreds of high-confidence […]

Machine learning endows autonomous systems to uncover underlying structures and physical laws from measured data and to leverage these models for prediction and decision-making. As the costs of data acquisition, […]

Collaborative virtual reality environments have the potential to greatly impact scientific progress, especially those relating to existential human problems. Within these virtual environments, scientists could view and interact with spatial […]

Program verification has been applied in many contexts (including videogames), but the scale and complexity of the examples that have been analyzed fall short of the ability to analyze many […]