Lucas, J. (BMEB) – Enabling Population-Scale Analysis of Human Centromere Diversity
Centromeric DNA is critical for accurate chromosome segregation and genome stability, but due to its repetitive nature, it was only recently fully included in a human reference. Rapid evolution and sequence diversity in these regions limit the utility of one reference sequence, however. Integrating centromeric and pericentromeric satellite DNA – which together constitute over 5% […]