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DTSTART;TZID=America/Los_Angeles:20260925T103000
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SUMMARY:ECE Special Seminar: "Autonomous Electric Vehicles – Data Centers on the Wheel"
DESCRIPTION:Presented by: Kaushik Rajashekara\, Hugh Roy and Lillie Cranz Cullen Distinguished University Professor @ University of Houston \nDescription: “Autonomous electric vehicles (AEVs) are at the forefront of modern transportation\, merging automation with sustainability to enhance efficiency and safety while reducing environmental impact. However\, these vehicles face significant challenges in balancing the energy demands of autonomous compute systems with propulsion efficiency and vehicle range. The sensors\, LiDAR\, cameras\, and AI inference hardware required for Level 4 autonomy draw significant continuous compute power — entirely separate from propulsion. This power is comparable to a server-class GPU — making each AEV\, in effect\, a data center on wheels. This presentation explores that compute energy load\, examines how it scales across projected global AV fleets\, and compares it with the energy consumption and CO₂ emissions of global data centers. The presentation concludes with current challenges and future trends in the key enabling technologies — next-generation batteries\, wide-bandgap power electronics\, high-efficiency electric machines\, and can scale without proportionally scaling its energy and emissions footprint.” \nBio: Kaushik Rajashekara (Fellow\, IEEE) received the Ph.D. degree in electrical engineering from the Indian Institute of Science\, Bangalore\, India. He held various lead technical and managerial positions at Delphi/General Motors (1989–2006)\, serving as Technical Fellow and Chief Scientist for propulsion and power electronics systems for electric\, hybrid\, and fuel cell vehicles.From 2006 to 2012\, he was Chief Technologist and Rolls-Royce Fellow for electric systems for electric and hybrid electric aircraft at Rolls-RoyceCorporation. From 2012 to 2016\, he was a Distinguished Professor at the University of Texas at Dallas. He is currently the Hugh Roy and Lillie Cranz Cullen Distinguished University Professor at the University of Houston. \nHe has authored over 300 papers and one book\, holds 37 U.S. and 15 foreign patents\, and has delivered over 250 invited presentations worldwide. His honors include the Global Energy Prize\, the IEEE Medal for Environmental and Safety Technologies\, and the IEEE Richard Harold Kaufmann Award. He is a member of the U.S. National Academy of Engineering\, a Fellow of the National Academy of Inventors\, aFellow of the European Academy of Sciences\, and an International Fellow of the Indian\, Chinese\, Canadian\, and Japanese Academies of Engineering. His research interests include power conversion\, transportation electrification\, renewable energy\, offshore systems\, and microgrid systems. \n  \nHosted by: Professor Leila Parsa\, Electrical & Computer Engineering Department \nWhen: Friday\, September 25\, 2026 @ 10:30 AM PST \nLocation: E2-506 \n  \n 
URL:https://events.ucsc.edu/event/ece-special-seminar-autonomous-electric-vehicles-data-centers-on-the-wheel/
LOCATION:Engineering 2\, Engineering 2 1156 High Street\, Santa Cruz\, CA\, 95064
CATEGORIES:Seminars
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DTSTART;TZID=America/Los_Angeles:20260925T130000
DTEND;TZID=America/Los_Angeles:20260925T150000
DTSTAMP:20260911T151906Z
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SUMMARY:Mastoras\, M. (BMEB) - Polishing genome assemblies and leveraging their improved quality to study centromere variation
DESCRIPTION:A complete and accurate genome reconstruction serves as the foundation for studying an organism’s biology and the mechanisms underlying disease. It is particularly critical for reference genomes\, which provide a universal coordinate system for downstream genomic analysis. Errors or missing sequences in a reference genome create bias in all of the studies built on top of them. The Human Pangenome Reference Consortium (HPRC) seeks to address this bias by transitioning the field to a pangenome reference\, a graph based collection of many genome assemblies\, providing a better representation of variation in the human population. Removing errors in the HPRC assemblies is critical to ensure the pangenome serves as a robust standard for genomic variant discovery. In the first part of my thesis\, I improve the base level accuracy of the HPRC release 2 assemblies (HPRC2) with a machine learning model for assembly polishing called DeepPolisher. Next\, I make additional contributions to reference-based genomic analysis by polishing reference genomes of other model organisms\, and helping to develop a new method for de-novo assembly and variant calling from a single-flow cell nanopore sequencing protocol. Finally\, I take advantage of the highly accurate\, near complete assemblies from HPRC2 that I improved with DeepPolisher to study a region only recently made accessible to genomics analysis: the human centromere. I apply the tool Centrolign\, the first ever multiple-sequence-aligner for centromeres to the HPRC2 assemblies\, establishing precise estimates of mutation rates and spatial variation patterns across centromeric arrays. \nEvent Host: Mira Mastoras\, Ph.D. Candidate\, Biomolecular Engineering & Bioinformatics \nAdvisor: Benedict Paten \nZoom: https://ucsc.zoom.us/j/98960011053?pwd=mFKCwtSIhvT5FvEURbE85lRbbMvzuo.1 \nPasscode: 118488
URL:https://events.ucsc.edu/event/mastoras-m-bmeb-polishing-genome-assemblies-and-leveraging-their-improved-quality-to-study-centromere-variation/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Ph.D. Presentations
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DTSTART;TZID=America/Los_Angeles:20260925T150000
DTEND;TZID=America/Los_Angeles:20260925T160000
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SUMMARY:Malekos\, E. (BMEB) - CRISPR screens of noncanonical ORFs uncover retroviral-derived immune regulators
DESCRIPTION:Ribosome profiling has revealed thousands of noncanonical translation events across mammalian genomes\, yet functional characterization has overwhelmingly focused on proliferative fitness in cancer cell lines. Here\, we present a comprehensive survey of noncanonical translation in the mouse immune system and its functional consequences in macrophages. By performing a unified Ribo-seq meta-analysis across 20 public mouse leukocyte datasets – spanning macrophages\, dendritic cells\, neutrophils\, B cells\, and T cells – we define a compendium of 22\,276 noncanonical coding sequences (CDSs)\, including upstream ORFs (uORFs)\, downstream ORFs\, and ORFs on noncoding RNAs and pseudogenes (ncORFs). Proteogenomic integration with reanalyzed mass spectrometry data prioritizes a high-confidence subset with detectable protein products\, including pseudogene-encoded and lncRNA-encoded zinc finger proteins. To move beyond cataloging\, we carried out two orthogonal CRISPR screens in immortalized bone marrow-derived macrophages: a fitness screen identifying noncanonical CDSs required for macrophage viability\, and a TLR1/TLR2-NFκB reporter screen uncovering CDSs that modulate innate immune signaling. These screens nominate uORFs\, several conserved between mouse and human\, that exert phenotypic effects on par with their cognate coding sequences. We unexpectedly discovered a family of endogenous retroviral envelope-derived proteins translated in adult myeloid cells. Among these\, SYNIR is a full-length syncytin-like membrane glycoprotein that positively regulates NFκB-responsive transcription\, while SEMR is a secreted protein with structural homology to the feline leukemia virus accessory protein FeLIX that drives broad transcriptional remodeling of macrophage gene programs upon knockout. Updated single-cell RNA-seq annotations and an interactive UCSC Genome Browser session integrating Ribo-seq\, proteomics\, and CRISPR screen data are provided as community resources. Together\, these findings expand the functional landscape of noncanonical translation in immunity and establish endogenous retroviral proteins as previously unrecognized regulators of macrophage biology. \nEvent Host: Eric Malekos\, Ph.D. Candidate\, Biomolecular Engineering & Bioinformatics  \nAdvisor: Susan Carpenter
URL:https://events.ucsc.edu/event/malekos-e-bmeb-crispr-screens-of-noncanonical-orfs-uncover-retroviral-derived-immune-regulators/
LOCATION:Biomedical Sciences\, Biomedical Sciences Building Red Hill Road\, Santa Cruz\, CA\, 95064
CATEGORIES:Ph.D. Presentations
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DTSTART;TZID=America/Los_Angeles:20260925T180000
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SUMMARY:Boardwalk Frolic
DESCRIPTION:Kick off your UCSC experience with a night of fun at the Santa Cruz Beach Boardwalk! The Boardwalk Frolic is a private event just for new UCSC students—featuring free rides\, games\, and the chance to connect with fellow Banana Slugs right on the beach. Enjoy the lights\, the ocean breeze\, and one of Santa Cruz’s most iconic spots as you make new memories and new friends. \n  \nPurchase tickets in advance to avoid long wait lines at the Boardwalk! \n$20 for all UCSC Students* – purchase your ticket here! \n*Ticket price increases to $40 after 4\,500 student tickets are sold. \n\nUnlimited rides\n$10 MyBoardwalk Card valid for food\, games\, and retail\nFree mini golf\, laser tag\, fright walk\, and laser maze\nFree arcade play\nFree parking\nCampus shuttles to and from the Boardwalk\n\nShuttle Info: \nCampus to Boardwalk: Buses run from 4:30 p.m. – 8 p.m. ONLY. \nBoardwalk to Campus: Buses run from 8 p.m. – 11 p.m. ONLY*. \nShuttle Stops on Campus: \n\nStop 1 – Bay Tree/Cowell Stevenson bus stop\nStop 2 – Crown/Merrill bus stop\nStop 3 – College Nine/John R. Lewis College bus stop\nStop 4 – Porter/Rachel Carson bus stop\n\n*Shuttles going back to campus from the Boardwalk will stop running after 11 p.m. Any student who is not in line for a bus before 11 p.m. will need to arrange for their own ride back to campus. Santa Cruz Metro city busses also stop running at 11 p.m. \n 
URL:https://events.ucsc.edu/event/boardwalk-frolic/
LOCATION:Santa Cruz Beach Boardwalk
CATEGORIES:Social Gathering,Undergraduate
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