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DTSTART;TZID=America/Los_Angeles:20260423T114000
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SUMMARY:BME 280B Seminar: Speaker Dr. Aaron Newman - Molecular and spatial determinants of single-cell developmental states in cancer
DESCRIPTION:Presenter: Dr. Newman\, Associate Professor in the Department of Biomedical Data Science\, Stanford University \n  \nDescription: Determining the factors that shape cell potency—the ability of a cell to differentiate into other cell types—is essential for understanding tissue biology in health and disease\, including cancer. In previous work\, we found that single-cell transcriptional diversity decreases across developmental time\, from the fertilized egg to the most mature cells in the body\, and in multiple organisms. More recently\, we developed CytoTRACE 2\, an interpretable AI framework trained on millions of data points from single-cell RNA sequencing data\, to determine cell potency on an absolute scale and reveal molecular hallmarks of developmental potential. We are now leveraging this method along with advances in spatial transcriptomics\, to identify multicellular ecosystems linked to cancer cell differentiation states and clinical outcomes. I will highlight these tools along with our ongoing work to decode cell plasticity and clinically relevant spatial microenvironments in human malignancies. \n  \nBio: Dr. Newman is an Associate Professor in the Department of Biomedical Data Science at Stanford University and a Chan Zuckerberg Biohub Investigator. He is also a member of the Stanford Cancer Institute and the Stanford Institute for Stem Cell Biology and Regenerative Medicine. Dr. Newman has made significant contributions to computational biology with applications to liquid biopsy\, cancer genomics\, and tumor immunology. Key contributions include CAPP-Seq for ultrasensitive detection of circulating tumor DNA; CIBERSORT/x for decoding cellular composition from bulk genomic data; CytoTRACE/2 for inferring cellular differentiation states from scRNA-seq data; and EcoTyper for delineating context-dependent cellular ecosystems from bulk\, single-cell\, and spatial expression data. His research program focuses on developing innovative data science tools to study the phenotypic diversity\, differentiation hierarchies\, and clinical significance of tumor cells and their surrounding microenvironments. Key results are further explored experimentally\, both in the lab and through collaboration\, with the goal of translating promising findings into the clinic.  \nHosted by: Professor Camilla Forsberg\, BME Department
URL:https://events.ucsc.edu/event/molecular-and-spatial-determinants-of-single-cell-developmental-states-in-cancer/
LOCATION:Biomedical Sciences Building\, 575 McLaughlin Drive
CATEGORIES:Lectures & Presentations,Seminars
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DTSTART;TZID=America/Los_Angeles:20251211T180000
DTEND;TZID=America/Los_Angeles:20251211T193000
DTSTAMP:20260501T095509
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SUMMARY:Science in the Neighborhood: The End Game: Discovering how telomeres cause disease
DESCRIPTION:Science In the Neighborhood\nA public lecture series hosted quarterly by the UC Santa Cruz Science Division \nThe End Game: Discovering how telomeres cause disease\nPresentation by Carol Greider\, Professor\, UC Santa Cruz\nQ&A with Susan Carpenter\, Professor\, UC Santa Cruz \nTelomeres\, the ends of chromosomes\, play a pivotal role in human disease. Short telomeres cause age-related degenerative disease\, while long telomeres predispose people to cancer. That’s why understanding how telomere length is regulated is so critical. Dr. Greider’s research is uncovering the mechanism of telomere length regulation so that we can devise approaches for disease treatment. By using new DNA-sequencing technology in a novel way\, her team made a surprising discovery: Each chromosome end has a unique telomere-length distribution that is different from other chromosome ends. Dr. Greider will explain how this finding will help us better understand the role of telomeres in disease. \nThe event is in-person only. Register here. \nDecember 11\, 2025 | 6:00–7:30 p.m.\nCoastal Biology Building. Rm. 110\nUC Santa Cruz Coastal Campus\n130 McAllister Way\nSanta Cruz\, CA 95060 \nThe screenshot below shows where to find the entrance of the Coastal Biology Building.
URL:https://events.ucsc.edu/event/the-end-game-discovering-how-telomeres-cause-disease/
LOCATION:Coastal Biology Building\, 130 McAllister Way\, Santa Cruz\, CA\, 95060
CATEGORIES:Lectures & Presentations
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DTSTART;TZID=America/Los_Angeles:20251020T190000
DTEND;TZID=America/Los_Angeles:20251020T210000
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SUMMARY:Screening: Cracking the Code
DESCRIPTION:Please join us for a public screening of “Cracking the Code: Phil Sharp and the Biotech Revolution” at the Landmark Theater on Monday\, October 20. The screening will start at 7pm\, with a panel discussion hosted by the UCSC RNA Center to follow. \nThis powerful new documentary chronicles Nobel Laureate Phil Sharp’s discovery of RNA splicing\, a breakthrough that ignited the biotechnology revolution and continues to shape the future of medicine and innovation worldwide. Our city was chosen for a special screening of this film in recognition of UC Santa Cruz’s long-standing leadership in RNA research and its pivotal contributions to understanding RNA metabolism. \nRegister to attend \nMore than a film\, this evening is an opportunity to reflect on Santa Cruz’s place in the future of biotechnology and life sciences innovation. After the screening\, we will host a panel discussion themed “Why Not Santa Cruz?”—exploring how our region\, with its scientific excellence in RNA and Genomics\, entrepreneurial spirit\, and vibrant community\, might cultivate the next generation of discoveries\, companies\, and partnerships. \nWe expect a lively exchange among scientists\, community leaders\, philanthropists\, and innovation builders about how Santa Cruz can play a greater role in shaping the next wave of biotech breakthroughs. \nView trailer here \n 
URL:https://events.ucsc.edu/event/screening-cracking-the-code/
LOCATION:Landmark’s Del Mar Theatre
CATEGORIES:Concerts
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