Biomedical Sciences Building

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  • BME 280B Seminar 04232026

    BME 280B Seminar: Speaker Dr. Aaron Newman – Molecular and spatial determinants of single-cell developmental states in cancer

    Biomedical Sciences Building 575 McLaughlin Drive

    Presenter: Dr. Newman, Associate Professor in the Department of Biomedical Data Science, Stanford University   Description: Determining the factors that shape cell potency—the ability of a cell to differentiate into other cell types—is essential for understanding tissue biology in health and disease, including cancer. In previous work, we found that single-cell transcriptional diversity decreases across […]

  • BME 280B Seminar: Small changes, Big consequences: Modulators of Alphavirus Assembly

    Biomedical Sciences Building 575 McLaughlin Drive

    Presenter: Dr. Suchetana (Tuli) Mukhopadhyay, Professor, Indiana University Description: N/A Bio: Suchetana “Tuli” Mukhopadhyay, Ph.D., is a professor in the Department of Biology at Indiana University, Bloomington. She received her B.A. in chemistry from DePauw University and her Ph.D. in chemistry from the University of Illinois at Chicago. Following her doctoral studies, Mukhopadhyay conducted postdoctoral […]

  • Tran, L. (BMEB) – Polysome Shadowing: A Long-Read Sequencing Approach to Study Translation

    Biomedical Sciences Building 575 McLaughlin Drive

    Translation is a central and highly regulated step of gene expression, yet there are few quantitative, high-throughput tools to study translation. Existing methods such as sucrose gradients provide only bulk ribosome counts, while Ribo-Seq offers positional information in the genome but destroys long-range structure and transcript expression information. Because of these limitations, many fundamental questions […]

  • Shanks, C. (BMEB) – Development and Application of Local Ancestry Methods for Population Genomics

    Biomedical Sciences Building 575 McLaughlin Drive

    Local ancestry methods classify the segments of DNA inherited from a specific ancestry (e.g., African, East Asian, European), improving analyses of admixed populations. Aim 1 applies ancestry-specific analysis to more than 1000 whole genome sequences across Polynesia, revealing strong bottlenecks in the voyagers who settled both Hawaiʻi and Rapa Nui, and confirming frequencies of Mendelian […]

  • Leavitt, J. (BMEB) – Evolutionary Dynamics, Functional Adaptations in Stress Response, and Direct Detection of tRNA modifications in Archaea

    Biomedical Sciences Building 575 McLaughlin Drive

    Transfer RNA (tRNA) modifications are essential for structural integrity, decoding fidelity, and stress adaptation, yet their dynamics across phylogenetically distinct archaeal species and their functional roles during stress remain incompletely understood. This dissertation aims to address some of these gaps through a multi-scale investigation that spans the evolutionary dynamics, stress-responsive functions, and direct detection of […]

  • Katte, P. (BMEB) – Interactive and Scalable Frameworks for Pathogen Surveillance and Ancestral Recombination Graph

    Biomedical Sciences Building 575 McLaughlin Drive

    The explosive growth of genomic data, driven by advances in sequencing and inference technologies, presents both an opportunity and a challenge for evolutionary biology and public health. Existing visualization and analysis tools often fall short in handling the scale, complexity, and uncertainty of modern genomic datasets—especially in the areas of pathogen surveillance and ancestral recombination […]