Rose, N. (BMEB) – MACHINE LEARNING MODELS FOR T CELL RECEPTOR TARGET DISCOVERY AND AFFINITY ENGINEERING
T cell receptors (TCRs) mediate antigen-specific immune responses through recognition of peptides presented by major histocompatibility complex (pMHC) molecules. Accurately predicting TCR–pMHC interactions remains a major barrier to TCR-based immunotherapy, due to limitations in current models that fail to generalize beyond common viral epitopes and well-characterized HLA alleles. In this PhD proposal, I outline a […]