Modern AI systems demand low-latency high-quality retrieval and serving over billion-scale keys and vectors. This proposal studies learned hashing and overlay networks to co-locate semantically related items and steer queries […]
Advances in sequencing technologies have enabled the recovery of genetic data from minimal, contaminated, and highly degraded samples, overcoming long-standing barriers in forensic analysis. Nevertheless, many evidentiary samples still yield […]
This dissertation focuses on designing and proving performance guarantees on algorithms when there is uncertainty in the input. The uncertainty could be from the user being unsure or future inputs […]
One of the central challenges in quantum computing is finding or approximating the ground-state energy of a local Hamiltonian, a quantum analogue of classical constraint satisfaction problems (CSPs). Among these, […]
Miniaturized spectrometers have the potential to replace bulky and expensive benchtop models. We have previously demonstrated a multimode interference (MMI) waveguide-based spectrometer that achieves high performance while minimizing its footprint. […]
Organoids are three-dimensional tissue cultures that model real organs and serve as valuable tools for studying development, disease, and treatment response. Traditional methods, which rely on manual handling and incubators, limit consistency and real-time monitoring. To address these issues, we developed a modular microfluidic platform that integrates automated feeding, live fluorescence imaging, and environmental control […]
Most optimization problems face the challenge of computing an optimum solution requiring superpolynomial time. In particular, they are classified as NP-hard problems that have no polynomial-time algorithm to date. Instead, […]
Simulation is a coinductive proof technique to assert the behavioral equivalence of computing systems that has seen fruitful application in distributed systems, concurrent process calculi, and programming languages, since the […]
In this work, we develop numerical methods for conservation laws that explore statistical, structure-preserving, and machine-learning-based approaches, each built on top of traditional numerical solvers. First, we develop a general […]
Hardware design flows have become increasingly complex as modern chips integrate billions of transistors and rely on aggressive synthesis optimizations to meet performance, area, and power targets. While these transformations […]
Modern applications, such as data center workloads, have become increasingly complex. These applications primarily operate on massive datasets, which involve large memory footprints, irregular access patterns, and complex control and […]
Reinforcement Learning (RL) is a machine learning paradigm that trains a decision maker, or policy, by learning from interaction with an environment. The power of RL lies in its ability […]
Transient execution attacks are serious security threats in modern-day processors. Out-of-order execution compels the processor to access data that should not be otherwise perceived. Leakage of that secret information creates […]
The growing integration of Large Language Models (LLMs) into real-world applications has heightened concerns about their trustworthiness, as models may reveal private information, reproduce copyrighted content, propagate biases, or generate […]
While Large Language Models exhibit remarkable capabilities, their reliance on the standard Transformer architecture imposes prohibitive computational costs and quadratic memory complexity. To bridge the gap between biological efficiency and […]
Quantum Key Distribution (QKD) provides information-theoretic security for cryptographic key establishment, but existing protocols exhibit limited noise tolerance, restricting their applicability in practical quantum channels with finite resources. This work […]
Translation is a central and highly regulated step of gene expression, yet there are few quantitative, high-throughput tools to study translation. Existing methods such as sucrose gradients provide only bulk […]
Transcriptomic profiling has been transformative in pediatric oncology. Pediatric cancers arise from disrupted developmental programs. Their impaired transcriptional states reflect cell lineage infidelity, aberrant differentiation, and immune-microenvironment interactions distinct from those of adult tumors(Gröbner et al., 2018; X. Ma et al., 2018). Within the osteosarcoma (OS) landscape, despite being the most common bone tumor of […]
Today, both individual and collective memories are increasingly mediated by digital platforms. Both are fundamentally enmeshed in platform ecosystems that orient around commercial imperatives very much at odds with community cohesion. The digital archive where our mediated memories are stored does not merely store information but actively inscribes it, often privileging narratives aligned with commercial […]
Title: Understanding the advising praxes central to student success at a four-year Hispanic-Serving Research Institution Presenter: Dr. Lydia Iyeczohua Zendejas Location: Via Zoom (link provided via RSVP) Abstract: Higher education scholars increasingly recognize academic advising as a critical strategy for supporting the persistence of systemically marginalized students. Since the 1990s, UC Santa Cruz has undergone […]