Sequencing technologies have transformed population and evolutionary genetics, making it possible to ask questions at scales that were intractable a decade ago. Realizing that potential depends on tailored computational approaches, […]
Flow cytometry is a valuable technique in microbial research used to measure the optical properties of single-celled organisms at high throughput. Oceanographers often deploy flow cytometers on research cruises in order to study the characteristics of phytosynthetic microbes—called phytoplankton—in regions and times with diverse environmental conditions. Because cytometers cannot distinguish between subpopulations, researchers typically cluster […]
Oceanographic data, generated by modern technologies that measure biological systems across time, space, and cell populations, are often rich, high-dimensional, and highly heterogeneous. Such data provide valuable opportunities to study subcellular organization, cellular heterogeneity, and dynamic biological processes in marine environments. However, because marine plankton systems remain relatively understudied and less well characterized than many […]
Modern scientific studies increasingly rely on complex datasets exhibiting spatial and temporal dependence, particularly in social, environmental, and climate applications. This dissertation develops statistical models and computational methods for analyzing […]
Complex societal problems (e.g. wicked problems) such as those brought on by climate change can be addressed through a combination of Research through Design (RtD), co-design, and Serious Games (SG) […]
Most optimization problems face the challenge of computing an optimum solution requiring superpolynomial time. In particular, they are classified as NP-hard problems that have no polynomial-time algorithm to date. Instead, […]
Advances in microscopy have transformed our understanding of biological systems, yet the high cost and limited accessibility of commercial imaging platforms continue to re- strict their use in many research […]
Research on fault-tolerance protocols for approximate Byzantine agreement (ABA) has largely focused on ensuring that distributed processes remain consistent despite fewer than 1/3 faulty processes. Yet in many real systems, […]
Religion has historically been a profound force for global mobilization, shaping geopolitics, economies, and geography. Similarly, contemporary interactive media, with video games at the forefront, has moved beyond mere entertainment […]