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  • Close-up abstract image of a circuit board with glowing lines and interconnected pathways.

    Headrick, C. (BMEB) – The Regulation of mRNA Cleavage in Nonsense-mediated mRNA Decay: From Inside (intra-pathway determinants) Out (extra-pathway regulation)

    Biomedical Sciences Building 575 McLaughlin Drive

    Nonsense-mediated mRNA decay (NMD) is a translation-coupled quality control pathway that degrades mRNAs that harbor a premature termination codon (PTC) and 5-30% of normal cellular mRNAs. The NMD field sits at a pivotal moment with recent developments that endonucleolytic cleavage is the primary mechanism of mRNA decay conserved across metazoans. Discovery of a conserved NMD […]

  • Close-up abstract image of a circuit board with glowing lines and interconnected pathways.

    Mastoras, M. (BMEB) – Polishing genome assemblies and leveraging their improved quality to study centromere variation

    Physical Sciences Building Physical Sciences Building, Santa Cruz, CA
    Hybrid Event

    A complete and accurate genome reconstruction serves as the foundation for studying an organism’s biology and the mechanisms underlying disease. It is particularly critical for reference genomes, which provide a universal coordinate system for downstream genomic analysis. Errors or missing sequences in a reference genome create bias in all of the studies built on top […]

  • Three silhouetted figures talking, overlaid with graphics of digital data, charts, and technology interfaces.

    Malekos, E. (BMEB) – CRISPR screens of noncanonical ORFs uncover retroviral-derived immune regulators

    Biomedical Sciences Biomedical Sciences Building Red Hill Road, Santa Cruz, CA

    Ribosome profiling has revealed thousands of noncanonical translation events across mammalian genomes, yet functional characterization has overwhelmingly focused on proliferative fitness in cancer cell lines. Here, we present a comprehensive survey of noncanonical translation in the mouse immune system and its functional consequences in macrophages. By performing a unified Ribo-seq meta-analysis across 20 public mouse […]

  • Abstract digital illustration featuring gears and interconnected technology elements.

    Heath, H. (BMEB) – Linking Altered mRNA Processing to Translational Regulation in Lung Cancer

    Biomedical Sciences Biomedical Sciences Building Red Hill Road, Santa Cruz, CA
    Hybrid Event

    In lung cancer, recurrent alterations in RNA processing regulators reshape both the proteins genes encode and the sequences that regulate their production. Understanding how mRNA processing influences protein production requires resolving the coding and regulatory sequences present in individual mRNA isoforms. Transcription start site (TSS) choice, alternative splicing (AS) , and polyadenylation site (PAS) choice […]