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  • Three silhouetted figures talking, overlaid with graphics of digital data, charts, and technology interfaces.

    Malekos, E. (BMEB) – CRISPR screens of noncanonical ORFs uncover retroviral-derived immune regulators

    Biomedical Sciences Biomedical Sciences Building Red Hill Road, Santa Cruz, CA

    Ribosome profiling has revealed thousands of noncanonical translation events across mammalian genomes, yet functional characterization has overwhelmingly focused on proliferative fitness in cancer cell lines. Here, we present a comprehensive survey of noncanonical translation in the mouse immune system and its functional consequences in macrophages. By performing a unified Ribo-seq meta-analysis across 20 public mouse […]

  • Abstract digital illustration featuring gears and interconnected technology elements.

    Heath, H. (BMEB) – Linking Altered mRNA Processing to Translational Regulation in Lung Cancer

    Biomedical Sciences Biomedical Sciences Building Red Hill Road, Santa Cruz, CA
    Hybrid Event

    In lung cancer, recurrent alterations in RNA processing regulators reshape both the proteins genes encode and the sequences that regulate their production. Understanding how mRNA processing influences protein production requires resolving the coding and regulatory sequences present in individual mRNA isoforms. Transcription start site (TSS) choice, alternative splicing (AS) , and polyadenylation site (PAS) choice […]