Ph.D. Presentations

Name: Malekos, E. (BMEB) – CRISPR screens of noncanonical ORFs uncover retroviral-derived immune regulators
Start: 2026-09-25T15:00:00-07:00
End: 2026-09-25T16:00:00-07:00
Location: Biomedical Sciences

September 2026
Headrick, C. (BMEB) – The Regulation of mRNA Cleavage in Nonsense-mediated mRNA Decay: From Inside (intra-pathway determinants) Out (extra-pathway regulation)

September 21 @ 11:30 am – 12:30 pm

Biomedical Sciences Building 575 McLaughlin Drive

Nonsense-mediated mRNA decay (NMD) is a translation-coupled quality control pathway that degrades mRNAs that harbor a premature termination codon (PTC) and 5-30% of normal cellular mRNAs. The NMD field sits at a pivotal moment with recent developments that endonucleolytic cleavage is the primary mechanism of mRNA decay conserved across metazoans. Discovery of a conserved NMD […]
Mastoras, M. (BMEB) – Polishing genome assemblies and leveraging their improved quality to study centromere variation

September 25 @ 1:00 pm – 3:00 pm

Hybrid Event

A complete and accurate genome reconstruction serves as the foundation for studying an organism’s biology and the mechanisms underlying disease. It is particularly critical for reference genomes, which provide a universal coordinate system for downstream genomic analysis. Errors or missing sequences in a reference genome create bias in all of the studies built on top […]
Malekos, E. (BMEB) – CRISPR screens of noncanonical ORFs uncover retroviral-derived immune regulators

September 25 @ 3:00 pm – 4:00 pm

Ribosome profiling has revealed thousands of noncanonical translation events across mammalian genomes, yet functional characterization has overwhelmingly focused on proliferative fitness in cancer cell lines. Here, we present a comprehensive survey of noncanonical translation in the mouse immune system and its functional consequences in macrophages. By performing a unified Ribo-seq meta-analysis across 20 public mouse […]

September 2026