Events

Centromeres ensure proper chromosome segregation during cell division, yet the organization and regulation of centromeric chromatin within satellite DNA arrays remain incompletely understood. Here, we leverage the complete diploid human genome benchmark (T2T-HG002) to provide a detailed study of centromeric sequence and chromatin architecture on individual haplotypes. Using adaptive-sampling-enriched, ultra-long-read DiMeLo-seq, we achieve single-molecule chromatin […]

As quantum computing transitions from theory to practice, understanding which algorithms suit near-term devices becomes critical. Current quantum computers are severely constrained by limited qubit counts, short coherence times, and high error rates that quickly degrade computation into noise. This thesis addresses two interconnected questions: what non-trivial computational tasks can near-term devices execute and how […]

Many genetics pipelines start by aligning sequencing reads to a reference genome. Aligners attempt to find the position in the reference sequence which best matches the read sequence, but this breaks down when the reads come from a sample with variation relative to the reference. A proposed alternative, pangenome graphs, is supposed to fix such […]