Condon, C. (BMEB) – Genomic conflict across scales
Genomes are often viewed as cooperative systems in which genes work together to support organismal function. Yet genetic elements can also act in ways that favor their own transmission or […]
The Biomolecular Engineering (BME) Department within the Baskin School of Engineering features an interdisciplinary blend of engineering, biology, chemistry, and statistics designed to foster collaboration with other departments. This blend reflects our vision of the direction that biomedical discovery will take over the next two decades.
Genomes are often viewed as cooperative systems in which genes work together to support organismal function. Yet genetic elements can also act in ways that favor their own transmission or […]
Host-microbe systems are core to some of biology’s most consequential interactions, from the pathogens that drive infectious disease to symbionts affecting agricultural pest control and vector-borne disease transmission. Yet unlike the model organisms that have driven most of modern molecular biology, the microbes at the center of these interactions are rarely genetically tractable: many cannot […]
The 26th Annual UC Systemwide Bioengineering Symposium (BIC 2026) is taking place at UC Santa Cruz on August 22-23, 2026. The event will bring together faculty, researchers, students, industry representatives, non-profit organizations, and other stakeholders to explore bioengineering & AI in the heart of the redwood forest. BIC 2026 will foster new collaborations and showcase […]
The 26th Annual UC Systemwide Bioengineering Symposium (BIC 2026) is taking place at UC Santa Cruz on August 22-23, 2026. The event will bring together faculty, researchers, students, industry representatives, non-profit organizations, and other stakeholders to explore bioengineering & AI in the heart of the redwood forest. BIC 2026 will foster new collaborations and showcase […]
The COVID-19 pandemic generated genomic data at unprecedented scale, with tens of millions of SARS-CoV-2 genomes deposited in public repositories and thousands of new sequences added each day. This dissertation develops methods for analyzing genomic datasets at this scale, unified by the idea that encoding genomes according to their evolutionary relationships can make otherwise intractable […]
Many somatic variant-calling pipelines begin by aligning tumor and matched-normal sequencing reads to a single linear reference genome, such as GRCh38. Because every individual differs substantially from this reference, this […]